It’s important that doctors discuss these symptoms with patients so they’re easily recognized. Patients often describe symptoms as a soreness, tiredness or weakness in the muscles. After reviewing the latest evidence, their expert panel highlights the importance of recognizing side effects of statins, which can range from mild muscle discomfort to severe pain that gets in the way of daily activities. The European Atherosclerosis Society has recently released guidelines for the diagnosis and management of muscle pain associated with statin use. In some cases, lifestyle changes like eating healthy and staying active aren’t enough to reduce risk of life-threatening heart events. High cholesterol is a major risk factor for heart attack and stroke. For some individuals, this side effect makes it seem like the benefit of taking the medication isn’t worth it-a serious problem.įor patients with high cholesterol, statins are often critical to achieving target cholesterol levels. It’s estimated that as many as one-third of patients taking statins experience this side effect. Muscle pain is one of the top reasons why patients taking statins fail to take them as prescribed or stop taking them altogether. doi:10.Muscle pain is the most common side effect associated with cholesterol-lowering statins, but there are ways to help patients reach targeted cholesterol levels while minimizing symptoms, according to a clinical update recently published in the European Heart Journal. Composition and potential health benefits of pomegranate: a review. Grapefruit and its biomedical, antigenotoxic and chemopreventive properties. Food-drug interactions precipitated by fruit juices other than grapefruit juice: an update review. Grapefruit juice and some drugs don't mix.Ĭhen M, Zhou SY, Fabriaga E, et al. Inhibitory effects of fruit juices on CYP3A activity. Rhabdomyolysis associated with pomegranate juice consumption. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents. Oral allergy syndrome in birch pollen-sensitized patients from a korean university hospital. Pomegranates as a rare cause of anaphylaxis in a school child. Astragalus membranaceus and punica granatum alleviate infertility and kidney dysfunction induced by aging in male rats. Therapeutic effects of Punica granatum (pomegranate): an updated review of clinical trials. Punica granatum (pomegranate) activity in health promotion and cancer prevention. The antiplaque efficacy of pomegranate mouthrinse. Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. Could pomegranate juice help in the control of inflammatory diseases? Nutrients. National Institutes of Health, National Center for Complementary and Integrative Health. Vasculoprotective effects of pomegranate ( Punica granatum L.). Complementary Therapies in Clinical Practice. The effects of pomegranate juice consumption on blood pressure and cardiovascular health. BMC Complementary and Alternative Medicine. The effect of pomegranate fresh juice versus pomegranate seed powder on metabolic indices, lipid profile, inflammatory biomarkers, and the histopathology of pancreatic islets of langerhans in streptozotocin-nicotinamide induced type 2 diabetic sprague-dawley rats. Taheri Rouhi SZ, Sarker MMR, Rahmat A, et al. Effects of pomegranate juice on blood pressure: a systematic review and meta-analysis of randomized controlled trials. Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial. The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction: a meta-analysis and systematic review. Chemical composition, antioxidant activity, and sensory characterization of commercial pomegranate juices. Effects of pomegranate juice on cardiovascular risk factors in patients with metabolic syndrome: a double-blinded, randomized crossover controlled trial.
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